Verzenio® Patient Stories for Metastatic Breast Cancer (MBC)

Patient stories

Real stories from real women living with metastatic breast cancer.

Real Relentless Women

Hear from real, relentless women living with metastatic breast cancer. For some, this includes Verzenio and how the treatment has impacted their story.

Video thumbnail for The Next Verse: Stories of Strength and Connection, elderly woman with glasses — **00:00-00:11**

[The Verzenio abemaciclib 50 | 100 | 150 | 200 mg tablets logo is to the left of the captions.]

**Caption:** Verzenio is a prescription medicine used to treat a type of breast cancer in adults. It is a medicine:

You can take if you have a type of breast cancer called HR+, HER2– (hormone receptor positive, human epidermal growth factor receptor 2 negative) and the cancer has spread to other parts of the body (metastasized)

That is given with an aromatase inhibitor as initial endocrine-based therapy. If the cancer has gotten worse after hormone therapy, then Verzenio is given with fulvestrant. If the cancer has gotten worse after both hormone therapy and chemotherapy, then Verzenio is given by itself

It is not known if Verzenio is safe and effective in children.

**Caption:** Individual results may vary. Statements made in this video are unique to Nancy's individual experience on Verzenio in combination with hormone therapy. Please read the Indication and Safety Summary following this video. Patient was compensated for her time.

**00:12-00:26**

[A series of photographs of Nancy with her family and grandchildren appear on screen. The Verzenio logo and the Verzenio Continuous Care™ logo (from 20 second) are in the top left corner.]

**AVO:** Meet one real, relentless woman taking Verzenio in combination with hormone therapy for her HR+, HER2– metastatic breast cancer. And learn more about the support she received from the Verzenio Continuous Care™ Program.

**Caption:** Meet one real, relentless woman taking Verzenio in combination with hormone therapy for her HR+, HER2– metastatic breast cancer. And learn about the support she received from the Verzenio Continuous Care™ Program.

**Caption:** The Verzenio Continuous Care Team is not made up of medical professionals. Your doctor is your source for medical advice. Once prescribed Verzenio, you are eligible to enroll in the program.

**00:27-00:36**

[The Verzenio Continuous Care™ logo is center screen.]

**AVO:** Verzenio Continuous Care can help you get started on Verzenio, navigate the insurance process, answer any questions you might have or just lend an ear if you need someone to talk to.

**Caption:** Getting started on Verzenio. Navigate the insurance process. Answer your questions. Lend an ear.

**Caption:** The Verzenio Continuous Care Team is not made up of medical professionals. Your doctor is your source for medical advice. Once prescribed Verzenio, you are eligible to enroll in the program.

**00:37-01:06**

[Cut to a close-up of Nancy looking happy at home. The camera pans to a few photos of Nancy with her grandchildren. The Verzenio Continuous Care™ logo is in the upper left corner.]

**Nancy:** My name is Nancy. I am proud to say that I am 71 years old. I have a total of four grandchildren. They are the light of my life. I love watching what they do. I wish I had more but that's not up to me. It's extremely important for me to be present; good times, bad times, whatever it is. I will show up and maybe it just means I stand there.

**Caption:** The next verse: stories of strength and connection. Nancy.

**Caption:** Nancy, actual patient living with HR+, HER2– MBC.

**01:07-01:23**

[Cut to more photos of Nancy with her grandchildren and family.]

**Nancy:** I was very angry when I found out I had metastatic breast cancer. I had done this whole cancer thing 10 years previous. Had been through surgery, radiation, chemo and so when this came up, I was like this just isn't fair.

**01:24-01:40**

[Continue to pan over photos of Nancy with her family. The Verzenio logo is in the bottom right corner.]

**Nancy:** When my doctor suggested that I take Verzenio, there was really no question in my mind that I wouldn't take it. To be able to slow this progression, it is allowing me time with my family and friends and that's all that's important.

**Caption:** Verzenio + an aromatase inhibitor delayed disease progression for a median of 28.2 months vs 14.8 months with an aromatase inhibitor alone. Individual results may vary. Statements made in this video are unique to Nancy's individual experience on Verzenio in combination with an aromatase inhibitor. Clinical trials are still ongoing to see if there is an overall survival benefit.

**01:41-02:05**

[Pan over photos of Nancy with her family, friends and enjoying a day out on a boat with her granddaughter. Cut to a photo in a frame of Nancy with her family. The Verzenio Continuous Care™ logo is in the bottom right corner.]

**Nancy:** Verzenio Continuous Care has helped me afford this medicine and to stay on it and to continue to be well for a while. From an emotional point of view, to be able to just get this stuff in the mail and know I have it's just...it's one less thing I have to worry about. For me, the most important treatment is that you continue to have hope.

**02:06-02:15**

[Transition to a woman (the poet) now holding the framed photo. She puts down the frame and takes out a fountain pen and paper. She sits down and starts to write. We cut and she's finishing her poem and puts the pen cap back on. The Verzenio logo is in the bottom right corner.]

**AVO:** A poet surprised Nancy by capturing her relentless spirit in a poem.

**Caption:** A poet surprised Nancy by capturing her relentless spirit in a poem.

**Caption:** Poet and poem are not offerings of the Verzenio Continuous Care Program.

**02:16-03:58**

[Cut to an exterior shot of Nancy's house. Nancy opens the door and receives a parcel. She sits down in her living room and opens the gift box addressed to her.]

**Nancy:** Thank you! Wow, wonder what this is! This is pretty exciting! It says, "For Nancy."

[She sits down in her living room and opens the gift box addressed to her. Inside is a small recording device. She places it down and presses play to listen to the recording.]

**Recording of Poet:** Hi Nancy, this is Farrah. Thank you so much for that wonderful interview along with your items. Your story really inspired me and I know it will inspire others—I hope you're inspired by my poem. Much love to you. Nancy; the giver, the nurturer, the art within the art, the thread that pulls everything together when it all falls apart. You stand on the shoulders of hope and never accept the defeat. Your unwavering strength enhances your joie de vivre. The joy of living like reading to your grandchildren. The art of giving and caring about the human condition. We're only as strong as the people we stand next to. That's why Verzenio is honored to stand with you.

**Caption:** Verzenio is honored to stand with you.

**Recording of Poet:** Verzenio Continuous Care empowers the same way it supports.

**Caption:** Verzenio Continuous Care empowers the same way it supports.

[Nancy keeps listening to the poem. The Verzenio Continuous Care™ logo is in the bottom right corner.]

**Recording of Poet:** Every brave step, quiet work and good deed circles back to the precious moments we get to share with family.

**Nancy:** Well, I'm crying, I knew I would. That was beautiful. I feel extremely grateful and humble and I want to just kind of sob my eyes out a bit but I won't.

**03:59-04:20**

[Cut back to the exterior shot of Nancy's home and then to Nancy in her living room. The Verzenio Continuous Care™ logo is in the bottom right corner.]

**Nancy:** Do I feel listened to by Verzenio? Absolutely. They call. They ask me how I'm doing, if I'm having any problems. If you quit hoping; you're going to quit living. If you have the hope, it frees you up to live.

**04:21-04:30**

[The Verzenio Continuous Care™ logo is centered on the screen.]

**AVO:** Verzenio Continuous Care. Personalized care that's here for you. To learn more or enroll in the program visit verzenio.com/support.

**Captions:** Personalized care. Here for you. To learn more or to enroll, visit verzenio.com/support

**Caption:** The Verzenio Continuous Care Team is not made up of medical professionals. Your doctor is your source for medical advice. Once prescribed Verzenio, you are eligible to enroll in the program.

**04:31-05:48**

[The Verzenio logo is in the bottom right corner.]

**AVO/Caption: INDICATION AND SAFETY SUMMARY**

Verzenio^® (ver-ZEN-ee-oh) is used to treat certain types of breast cancer known as HR+/HER2– (hormone receptor positive/human epidermal growth factor receptor 2 negative) breast cancer.

It is a medicine you can take if:

The cancer has spread to other parts of the body (metastasized). If you are female or male, then Verzenio is given with an aromatase inhibitor as initial endocrine-based therapy. If you are a female or male, and the cancer has gotten worse after hormonal therapy, then Verzenio is given with fulvestrant. If you are female or male and the cancer has gotten worse after both hormonal therapy and chemotherapy, then Verzenio is given by itself.

It is not known if Verzenio is safe and effective in children.

**Warnings - Verzenio may cause serious side effects, including:**
Diarrhea is common with Verzenio, may sometimes be severe and may cause dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. If you develop diarrhea during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, stop your treatment, or decrease your dose.

If you have any loose stools, start taking an antidiarrheal medicine (such as loperamide), drink more fluids, and tell your healthcare provider right away.

**05:49-07:36**

[The Verzenio logo is in the bottom right corner.]

**Caption: INDICATION AND SAFETY SUMMARY**

**AVO/Caption:** Low white blood cell counts (neutropenia) are common with Verzenio and may cause serious infections that can lead to death. Your healthcare provider should check your white blood cell counts before and during treatment. If you develop low white blood cell counts during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, decrease your dose, or wait before starting your next month of treatment. Tell your healthcare provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.

Verzenio may cause severe or life-threatening inflammation (swelling) of the lungs during treatment that can lead to death. If you develop lung problems during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, decrease your dose, or stop your treatment. Tell your healthcare provider right away if you have any new or worsening symptoms, including:

Trouble breathing or shortness of breath

Cough with or without mucus

Chest pain

Verzenio can cause serious liver problems. Your healthcare provider should do blood tests to check your liver before and during treatment. If you develop liver problems during treatment with Verzenio, your health care provider may reduce your dose or stop your treatment. Tell your healthcare provider right away if you have any of the following signs or symptoms of liver problems:

Feeling very tired

Pain on the upper right side of your stomach area (abdomen)

Loss of appetite

Bleeding or bruising more easily than normal

Verzenio may cause blood clots in your veins, or in the arteries of your lungs. Verzenio may cause serious blood clots that have led to death. If you develop blood clots during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it. Tell your healthcare provider right away if you have any of the following signs and symptoms of a blood clot:

Pain or swelling in your arms or legs

Shortness of breath

Chest pain

Fast breathing

Fast heart rate

**07:37-09:00**

[The Verzenio logo is in the bottom right corner.]

**Caption: INDICATION AND SAFETY SUMMARY**

**AVO/Caption:** Verzenio can harm your unborn baby. Use effective birth control (contraception) during treatment and for 3 weeks after the last dose of Verzenio and do not breastfeed during treatment with Verzenio and for at least 3 weeks after your last dose. Verzenio may affect the ability of males to father a child.

**Common side effects**

The most common side effects of Verzenio include:

Nausea

Infections

Low red blood cell counts (anemia)

Decreased appetite

Headache

Hair thinning or hair loss (alopecia)

Abdominal pain

Tiredness

Low white blood cell counts (leukopenia)

Vomiting

Low platelet counts (thrombocytopenia)

These are not all the possible side effects of Verzenio.

Tell your healthcare provider if you have any side effects. **You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.**

**AVO/Caption: Before using**

Before you use Verzenio, tell your healthcare provider about all your medical conditions, including:

If you have fever, chills, or other signs of infection.

If you have a history of blood clots in your veins.

Have lung or breathing problems.

Have liver or kidney problems.

If you are pregnant, plan to become pregnant, or are breastfeeding.

About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take a medicine that contains ketoconazole.

**09:01-10:27**

[The Verzenio logo is in the bottom right corner.]

**Caption: INDICATION AND SAFETY SUMMARY**

**AVO/Caption: How to take**

Take Verzenio exactly as your healthcare provider tells you.

Your healthcare provider may change your dose if needed. Do not stop taking Verzenio or change the dose without talking to your healthcare provider.

Verzenio may be taken with or without food.

Swallow Verzenio tablets whole. Do not chew, crush, or split the tablets before swallowing. Do not take Verzenio tablets if they are broken, cracked, or damaged.

Take your doses of Verzenio at about the same time every day.

If you vomit or miss a dose of Verzenio, take your next dose at your regular time. Do not take 2 doses at the same time to make up for the missed dose.

**What to avoid during treatment**

Avoid taking ketoconazole during treatment with Verzenio. Tell your healthcare provider if you take a medicine that contains ketoconazole

Avoid grapefruit and products that contain grapefruit during treatment with Verzenio. Grapefruit may increase the amount of Verzenio in your blood

**Learn more**

Verzenio is a prescription medicine. For more information, call 1-800-545-5979 or go to **verzenio.com**.

This summary provides basic information about Verzenio but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Verzenio and how to take it. Your healthcare provider is the best person to help you decide if Verzenio is right for you.

**Caption:** AL CON BS_MBC 03MAR2023

**AVO/Caption:** Verzenio^® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

**10:28-10:40**

[The Verzenio, Verzenio Continuous Care™ and Lilly logos appear on screen.]

**Caption:** Enroll today

For pricing information, please visit **lillypricinginfo.com/verzenio** or call **1-844-VERZENIO (1-844-837-9364)**.

PP-AL-US-3855 08/2023 ©Lilly USA, LLC 2023. All rights reserved.

Verzenio Continuous Care™ and Companion in Care™ are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

Verzenio^® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

Nancy

For Nancy, a real Verzenio patient, being there for her family is everything to her. She talks about her feelings about her diagnosis as well as how treatment with Verzenio has helped her feel more hopeful.

Video thumbnail for A Mother's Purpose. A Daughter's Admiration, middle-aged woman — **00:00-00:13**

[The Verzenio abemaciclib 50 |100 | 150 | 200 mg tablets logo is to the left of the captions.]

**Caption:** Verzenio is a prescription medicine used to treat a type of breast cancer in adults. It is a medicine:

You can take if you have a type of breast cancer called HR+, HER2– (hormone receptor positive, human epidermal growth factor receptor 2 negative) and the cancer has spread to other parts of the body (metastasized)

That is given with an aromatase inhibitor as initial endocrine-based therapy. If the cancer has gotten worse after hormone therapy, then Verzenio is given with fulvestrant. If the cancer has gotten worse after both hormone therapy and chemotherapy, then Verzenio is given by itself

It is not known if Verzenio is safe and effective in children.

**Caption:** Individual results may vary. Statements made in this video are unique to Teresa's individual experience on Verzenio in combination with fulvestrant. Please read the Indication and Safety Summary following this video. Patient was compensated for her time.

**00:14-00:46**

**Caption:** Real Relentless Women. A mother's purpose, a daughter's admiration.

[Teresa and her daughter are shopping for party supplies. Cut to Teresa sitting in her living room. The scene cuts between Teresa shopping with her daughter and in her living room.]

**Teresa:** My name is Teresa. I'm a wife of 35 years, a mom to four, a grandma of twin girls—they are turning two—so we are having a party to celebrate that. My parents will be here, and then my kids and my husband, naturally [laughs].

**Caption:** Teresa. Real relentless woman taking Verzenio.

**00:47-01:09**

[Cut to Teresa driving and arriving at a house. Teresa and her daughter are setting up for her granddaughters' birthday party. Transition back to Teresa in her living room.]

**Teresa:** A year ago, I was diagnosed with breast cancer—metastatic. I get scans on a regular basis and take Verzenio. The scans show that the tumors are shrinking and that's what we want. And so, it's working.

**Caption:** 48.1% of women on Verzenio + fulvestrant saw their tumors shrink vs. 21.3% with fulvestrant alone. Clinical trials are ongoing to determine if there is an overall survival benefit.

**Caption:** Individual results may vary. Statements made in this video are unique to Teresa's individual experience on Verzenio in combination with fulvestrant.

**01:10-01:26**

[The scene continues to cut between the birthday party and Teresa in the living room. Guests start to arrive for the birthday party and Teresa greets them with a hug as they come in.]

**Teresa:** I don't give up. Nothing would keep me down. Nope, no [shakes her head "No"]. I haven't missed a day of work. As long as the medication is working then I can just do what I do every day.

**Caption:** Monica, Teresa's Daughter.

**Caption:** Individual results may vary. Statements made in this video are unique to Teresa's individual experience on Verzenio in combination with fulvestrant.

**01:27-02:38**

**Caption:** Monica wanted Teresa to know how much she means to everyone around her.

So, we gave her a chance to tell her mom in an unexpected way.

[Teresa is with her family and friends sitting around the kitchen table at the birthday party. Cut between Teresa holding her granddaughters at the party and sitting around the kitchen table.]

**Offscreen Voice:** Monica's got a present.

**Monica:** I have a present. [Opens a letter and starts to read]. "Dear Mom, I wanted to write to you to share how inspirational you are—not only to me but to everyone standing around you today. You're a wonderful mother, always giving of yourself and never asking or even accepting anything in return. Your mom skills are good, but your grandma skills—perfection. You don't always get to see the way Caroline and Samantha's faces light up when your name is mentioned, but imagine it even more special and excited than when cookies are offered to them. Thank you for fiercely loving my girls. Thank you for showing me and all those around you how to demonstrate faith in the midst of doubt and fear. Thank you for always being the one I can rely on, for being relentless. I love you. Monica."

[Teresa gives Monica a big hug.]

**02:39-03:13**

[Transition to one of her granddaughters running up to Teresa. She picks her up and gives her a kiss. Cut between Teresa sitting in the living room and at the party with her family.]

**Teresa:** You put one foot in front of the other. Enjoy the little things. You rely on each other. Have faith. Do what makes you happy. What I'm looking forward to is watching my grandbabies grow. Yeah, I'm strong. I'm stronger than I ever knew.

**03:14-03:21**

[Transition from Teresa, her daughter and grandchildren at the birthday party to the caption. The Verzenio and Lilly logos appear in the bottom left and right corners, respectively.]

**Caption:** To the relentless women who inspire us every day, we're with you.

**03:22-04:41**

[The Verzenio logo is in the bottom right corner.]

**AVO/Caption: INDICATION AND SAFETY SUMMARY**

Verzenio^® (ver-ZEN-ee-oh) is used to treat certain types of breast cancer known as HR+/HER2– (hormone receptor positive/human epidermal growth factor receptor 2 negative) breast cancer.

It is a medicine you can take if:

The cancer has spread to other parts of the body (metastasized). If you are female or male, then Verzenio is given with an aromatase inhibitor as initial endocrine-based therapy. If you are a female or male, and the cancer has gotten worse after hormonal therapy, then Verzenio is given with fulvestrant. If you are female or male and the cancer has gotten worse after both hormonal therapy and chemotherapy, then Verzenio is given by itself.

It is not known if Verzenio is safe and effective in children.

**Warnings - Verzenio may cause serious side effects, including:**
Diarrhea is common with Verzenio, may sometimes be severe and may cause dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. If you develop diarrhea during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, stop your treatment, or decrease your dose.

If you have any loose stools, start taking an antidiarrheal medicine (such as loperamide), drink more fluids, and tell your healthcare provider right away.

**04:42-06:28**

[The Verzenio logo is in the bottom right corner.]

**Caption: INDICATION AND SAFETY SUMMARY**

**AVO/Caption:** Low white blood cell counts (neutropenia) are common with Verzenio and may cause serious infections that can lead to death. Your healthcare provider should check your white blood cell counts before and during treatment. If you develop low white blood cell counts during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, decrease your dose, or wait before starting your next month of treatment. Tell your healthcare provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.

Verzenio may cause severe or life-threatening inflammation (swelling) of the lungs during treatment that can lead to death. If you develop lung problems during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, decrease your dose, or stop your treatment. Tell your healthcare provider right away if you have any new or worsening symptoms, including:

Trouble breathing or shortness of breath

Cough with or without mucus

Chest pain

**AVO/Caption:** Verzenio can cause serious liver problems. Your healthcare provider should do blood tests to check your liver before and during treatment. If you develop liver problems during treatment with Verzenio, your health care provider may reduce your dose or stop your treatment. Tell your healthcare provider right away if you have any of the following signs or symptoms of liver problems:

Feeling very tired

Pain on the upper right side of your stomach area (abdomen)

Loss of appetite

Bleeding or bruising more easily than normal

Verzenio may cause blood clots in your veins, or in the arteries of your lungs. Verzenio may cause serious blood clots that have led to death. If you develop blood clots during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it. Tell your healthcare provider right away if you have any of the following signs and symptoms of a blood clot:

Pain or swelling in your arms or legs

Shortness of breath

Chest pain

Fast breathing

Fast heart rate

**06:29-07:53**

[The Verzenio logo is in the bottom right corner.]

**Caption: INDICATION AND SAFETY SUMMARY**

**AVO/Caption:** Verzenio can harm your unborn baby. Use effective birth control (contraception) during treatment and for 3 weeks after the last dose of Verzenio and do not breastfeed during treatment with Verzenio and for at least 3 weeks after your last dose. Verzenio may affect the ability of males to father a child.

**Common side effects**

The most common side effects of Verzenio include:

Nausea

Infections

Low red blood cell counts (anemia)

Decreased appetite

Headache

Hair thinning or hair loss (alopecia)

Abdominal pain

Tiredness

Low white blood cell counts (leukopenia)

Vomiting

Low platelet counts (thrombocytopenia)

These are not all the possible side effects of Verzenio.

Tell your healthcare provider if you have any side effects. **You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.**

**AVO/Caption: Before using**

Before you use Verzenio, tell your healthcare provider about all your medical conditions, including:

If you have fever, chills, or other signs of infection.

If you have a history of blood clots in your veins.

Have lung or breathing problems.

Have liver or kidney problems.

If you are pregnant, plan to become pregnant, or are breastfeeding.

About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take a medicine that contains ketoconazole.

**07:54-09:20**

[The Verzenio logo is in the bottom right corner.]

**Caption: INDICATION AND SAFETY SUMMARY**

**AVO/Caption: How to take**

Take Verzenio exactly as your healthcare provider tells you.

Your healthcare provider may change your dose if needed. Do not stop taking Verzenio or change the dose without talking to your healthcare provider.

Verzenio may be taken with or without food.

Swallow Verzenio tablets whole. Do not chew, crush, or split the tablets before swallowing. Do not take Verzenio tablets if they are broken, cracked, or damaged.

Take your doses of Verzenio at about the same time every day.

If you vomit or miss a dose of Verzenio, take your next dose at your regular time. Do not take 2 doses at the same time to make up for the missed dose.

**What to avoid during treatment**

Avoid taking ketoconazole during treatment with Verzenio. Tell your healthcare provider if you take a medicine that contains ketoconazole

Avoid grapefruit and products that contain grapefruit during treatment with Verzenio. Grapefruit may increase the amount of Verzenio in your blood

**Learn more**

Verzenio is a prescription medicine. For more information, call 1-800-545-5979 or go to **verzenio.com**.

This summary provides basic information about Verzenio but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Verzenio and how to take it. Your healthcare provider is the best person to help you decide if Verzenio is right for you.

**Caption:** AL CON BS_MBC 03MAR2023

**AVO/Caption:** Verzenio^® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

PP-AL-US-3859 08/2023 ©Lilly USA, LLC 2023. All rights reserved.

Teresa

Teresa, a wife, mother, grandmother, and a real Verzenio patient, talks about her experience living with metastatic breast cancer, and her daughter talks about how it has impacted their entire family.

Video thumbnail for One Sister's Purpose. The Other's Admiration, woman smiling — **00:00-00:13**

[The Verzenio abemaciclib 50 | 100 | 150 | 200 mg tablets logo is to the left of the captions.]

**Caption:** Verzenio is a prescription medicine used to treat a type of breast cancer in adults. It is a medicine:

You can take if you have a type of breast cancer called HR+, HER2– (hormone receptor positive, human epidermal growth factor receptor 2 negative) and the cancer has spread to other parts of the body (metastasized)

That is given with an aromatase inhibitor as initial endocrine-based therapy. If the cancer has gotten worse after hormone therapy, then Verzenio is given with fulvestrant. If the cancer has gotten worse after both hormone therapy and chemotherapy, then Verzenio is given by itself

It is not known if Verzenio is safe and effective in children.

**Caption:** Individual results may vary. Karen is not a Verzenio patient. Please read the Indication and Safety Summary following this video. Karen was compensated for her time.

**00:14-00:31**

**Caption:** Real Relentless Women.

**Caption:** One sister's purpose, the other's admiration.

[Karen is in her bedroom. She is waking up and getting ready for the day.]

**Karen:** I love the morning. Got things to do, places to go, people to see. I feel so vibrant. I'm so happy to be here.

**00:32-01:07**

[Karen sits down at her computer and starts typing. Cut to Karen in her living room speaking directly to the camera. Cut between Karen getting ready for the day and in her living room.]

My name is Karen and in January of 2017, I was diagnosed with breast cancer—stage 4. The diagnosis was shocking, of course, but at the same time I knew that I was going to change my narrative. I was going to research, and I was going to fight. I don't take "No" for an answer. You know, this is New Yok City, you either get down or lay down. You know, I want to stay alive, I think that's the basic answer, is that I want to stay alive.

**Caption:** Karen. Real Relentless Woman living with MBC. Not a Verzenio patient.

**01:08-01:37**

[Transition to various greeting cards Karen has received. Her sister and a friend arrive at her home. They walk down the streets of New York together and then they arrive at a fitness studio.]

**Karen:** You try to shield your loved ones from news like this. It's hard because they are going through it with you. My baby sister, I'm always protecting her. I wanted to let her know that I have a plan. Everything is going to be okay. I just need your help in order to be able to execute that plan. She never lets me just slack off, you know, just “woe is me”. No, she set up a low-impact fitness class today and I'm looking forward to it.

**Caption:** Pamela. Karen's sister.

**01:38-02:45**

**Caption:** Pamela wanted Karen to know how much she means to everyone around her.

So, we gave her a chance to tell her sister in an unexpected way.

[They enter the studio and Karen's sister, Pamela, reads her a letter. Cut to old family photos of Karen and Pamela. Transition to Karen, Pamela and their friend having fun at the fitness class. Cut to photos of Karen and her nieces.]

**Pamela:** Karen, I actually have a little something. "I can't say enough wonderful things about you. While many get to call you friend—I have the only distinction of being able to call you sister. While some people take that role lightly, you have always been there for me and the universe is brighter because of you. You've been my biggest champion, my fighter and my friend. I'm so proud of you and all that you've done. I'm so proud of your warrior spirit. Each time I find myself crying or ungrateful, I think about what you've had to fight for and yet you're still standing. You've always been my protector and I think you're such an inspiration. My girls see you marching down the streets of New York, and they're kind of parting the sidewalk. They are marching directly behind you and they're going 'That's my aunt, she's somebody special.' Your nieces and I are just honored to call you family. We love you."

[Karen gives Pamela a big hug.]

**02:46-03:01**

[Transition from Karen and Pamela hugging to Karen in her living room speaking directly to the camera. Cut back to the fitness studio; Karen, Pamela, and their friend all have a group hug.]

**Karen:** There's no reason for me to be gloom and doom when I'm still here and able to make a difference. To all of those who are in the struggle, keep going. Drive your own bus and feel empowered about that.

**03:02-03:08**

[Transition from Karen, Pamela, and their friend at the fitness studio to captions overlayed on screen. The Verzenio logo and Lilly logo appear on the bottom of the screen.]

**Caption:** To the relentless women who inspire us every day, we're with you.

**03:09-04:28**

[The Verzenio logo is in the bottom right corner.]

**AVO/Caption: INDICATION AND SAFETY SUMMARY**

Verzenio^® (ver-ZEN-ee-oh) is used to treat certain types of breast cancer known as HR+/HER2– (hormone receptor positive/human epidermal growth factor receptor 2 negative) breast cancer.

It is a medicine you can take if:

The cancer has spread to other parts of the body (metastasized). If you are female or male, then Verzenio is given with an aromatase inhibitor as initial endocrine-based therapy. If you are a female or male, and the cancer has gotten worse after hormonal therapy, then Verzenio is given with fulvestrant. If you are female or male and the cancer has gotten worse after both hormonal therapy and chemotherapy, then Verzenio is given by itself.

It is not known if Verzenio is safe and effective in children.

**Warnings - Verzenio may cause serious side effects, including:**
Diarrhea is common with Verzenio, may sometimes be severe and may cause dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. If you develop diarrhea during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, stop your treatment, or decrease your dose.

If you have any loose stools, start taking an antidiarrheal medicine (such as loperamide), drink more fluids, and tell your healthcare provider right away.

**04:29-06:15**

[The Verzenio logo is in the bottom right corner.]

**Caption: INDICATION AND SAFETY SUMMARY**

**AVO/Caption:** Low white blood cell counts (neutropenia) are common with Verzenio and may cause serious infections that can lead to death. Your healthcare provider should check your white blood cell counts before and during treatment. If you develop low white blood cell counts during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, decrease your dose, or wait before starting your next month of treatment. Tell your healthcare provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.

Verzenio may cause severe or life-threatening inflammation (swelling) of the lungs during treatment that can lead to death. If you develop lung problems during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, decrease your dose, or stop your treatment. Tell your healthcare provider right away if you have any new or worsening symptoms, including:

Trouble breathing or shortness of breath

Cough with or without mucus

Chest pain

**AVO/Caption:** Verzenio can cause serious liver problems. Your healthcare provider should do blood tests to check your liver before and during treatment. If you develop liver problems during treatment with Verzenio, your health care provider may reduce your dose or stop your treatment. Tell your healthcare provider right away if you have any of the following signs or symptoms of liver problems:

Feeling very tired

Pain on the upper right side of your stomach area (abdomen)

Loss of appetite

Bleeding or bruising more easily than normal

Verzenio may cause blood clots in your veins, or in the arteries of your lungs. Verzenio may cause serious blood clots that have led to death. If you develop blood clots during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it. Tell your healthcare provider right away if you have any of the following signs and symptoms of a blood clot:

Pain or swelling in your arms or legs

Shortness of breath

Chest pain

Fast breathing

Fast heart rate

**06:16-07:39**

[The Verzenio logo is in the bottom right corner.]

**Caption: INDICATION AND SAFETY SUMMARY**

**AVO/Caption:** Verzenio can harm your unborn baby. Use effective birth control (contraception) during treatment and for 3 weeks after the last dose of Verzenio and do not breastfeed during treatment with Verzenio and for at least 3 weeks after your last dose. Verzenio may affect the ability of males to father a child.

**Common side effects**

The most common side effects of Verzenio include:

Nausea

Infections

Low red blood cell counts (anemia)

Decreased appetite

Headache

Hair thinning or hair loss (alopecia)

Abdominal pain

Tiredness

Low white blood cell counts (leukopenia)

Vomiting

Low platelet counts (thrombocytopenia)

These are not all the possible side effects of Verzenio.

Tell your healthcare provider if you have any side effects. **You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.**

**AVO/Caption: Before using**

Before you use Verzenio, tell your healthcare provider about all your medical conditions, including:

If you have fever, chills, or other signs of infection.

If you have a history of blood clots in your veins.

Have lung or breathing problems.

Have liver or kidney problems.

If you are pregnant, plan to become pregnant, or are breastfeeding.

About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take a medicine that contains ketoconazole.

**07:40-09:07**

[The Verzenio logo is in the bottom right corner.]

**Caption: INDICATION AND SAFETY SUMMARY**

**AVO/Caption: How to take**

Take Verzenio exactly as your healthcare provider tells you.

Your healthcare provider may change your dose if needed. Do not stop taking Verzenio or change the dose without talking to your healthcare provider.

Verzenio may be taken with or without food.

Swallow Verzenio tablets whole. Do not chew, crush, or split the tablets before swallowing. Do not take Verzenio tablets if they are broken, cracked, or damaged.

Take your doses of Verzenio at about the same time every day.

If you vomit or miss a dose of Verzenio, take your next dose at your regular time. Do not take 2 doses at the same time to make up for the missed dose.

**What to avoid during treatment**

Avoid taking ketoconazole during treatment with Verzenio. Tell your healthcare provider if you take a medicine that contains ketoconazole

Avoid grapefruit and products that contain grapefruit during treatment with Verzenio. Grapefruit may increase the amount of Verzenio in your blood

**Learn more**

Verzenio is a prescription medicine. For more information, call 1-800-545-5979 or go to **verzenio.com**.

This summary provides basic information about Verzenio but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Verzenio and how to take it. Your healthcare provider is the best person to help you decide if Verzenio is right for you.

**Caption:** AL CON BS_MBC 03MAR2023

**AVO/Caption:** Verzenio^® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

PP-AL-US-3858 08/2023 ©Lilly USA, LLC 2023. All rights reserved.

Karen

Karen, a patient advocate living with metastatic breast cancer, talks about empowering women like her around the world. Her sister tells Karen what an inspiration her strength is to her and so many other women.

SELECT SAFETY INFORMATION

Verzenio may cause serious side effects, including:

Diarrhea is common with Verzenio, may be severe and may cause dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. If you develop diarrhea during treatment, your healthcare provider may tell you to temporarily stop taking it, stop your treatment, or decrease your dose. If you have any loose stools, start taking an antidiarrheal medicine (such as loperamide), drink more fluids, and tell your healthcare provider right away.

Learn more about Verzenio as a treatment option for HR+, HER2– metastatic breast cancer

Learn more

SAFETY SUMMARY

Warnings - Verzenio may cause serious side effects, including:

Diarrhea is common with Verzenio, may sometimes be severe and may cause dehydration or infection. The most common time to develop diarrhea is during the first month of Verzenio treatment. If you develop diarrhea during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, stop your treatment, or decrease your dose.

If you have any loose stools, start taking an antidiarrheal medicine (such as loperamide), drink more fluids, and tell your healthcare provider right away.

Low white blood cell counts (neutropenia) are common with Verzenio and may cause serious infections that can lead to death. Your healthcare provider should check your white blood cell counts before and during treatment. If you develop low white blood cell counts during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, decrease your dose, or wait before starting your next month of treatment. Tell your healthcare provider right away if you have signs and symptoms of low white blood cell counts or infections, such as fever and chills.

Verzenio may cause severe or life-threatening inflammation (swelling) of the lungs during treatment that can lead to death. If you develop lung problems during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it, decrease your dose, or stop your treatment. Tell your healthcare provider right away if you have any new or worsening symptoms, including:

Trouble breathing or shortness of breath
Cough with or without mucus
Chest pain

Verzenio can cause serious liver problems. Your healthcare provider should do blood tests to check your liver before and during treatment. If you develop liver problems during treatment with Verzenio, your health care provider may reduce your dose or stop your treatment. Tell your healthcare provider right away if you have any of the following signs or symptoms of liver problems:

Feeling very tired
Pain on the upper right side of your stomach area (abdomen)

Loss of appetite
Bleeding or bruising more easily than normal

Verzenio may cause blood clots in your veins, or in the arteries of your lungs. Verzenio may cause serious blood clots that have led to death. If you develop blood clots during treatment with Verzenio, your healthcare provider may tell you to temporarily stop taking it. Tell your healthcare provider right away if you have any of the following signs and symptoms of a blood clot:

Pain or swelling in your arms or legs
Shortness of breath
Chest pain

Fast breathing
Fast heart rate

Verzenio can harm your unborn baby. Use effective birth control (contraception) during treatment and for 3 weeks after the last dose of Verzenio and do not breastfeed during treatment with Verzenio and for at least 3 weeks after your last dose. Verzenio may affect the ability of males to father a child.

Common side effects

The most common side effects of Verzenio include:

Nausea
Infections
Low red blood cell counts (anemia)
Decreased appetite
Headache
Hair thinning or hair loss (alopecia)

Abdominal pain
Tiredness
Low white blood cell counts (leukopenia)
Vomiting
Low platelet counts (thrombocytopenia)

These are not all the possible side effects of Verzenio.

Tell your healthcare provider if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using

Before you use Verzenio, tell your healthcare provider about all your medical conditions, including:

If you have fever, chills, or other signs of infection.
If you have a history of blood clots in your veins.
Have lung or breathing problems.
Have liver or kidney problems.
If you are pregnant, plan to become pregnant, or are breastfeeding.
About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take a medicine that contains ketoconazole.

How to take

Take Verzenio exactly as your healthcare provider tells you.
Your healthcare provider may change your dose if needed. Do not stop taking Verzenio or change the dose without talking to your healthcare provider.
Verzenio may be taken with or without food.
Swallow Verzenio tablets whole. Do not chew, crush, or split the tablets before swallowing. Do not take Verzenio tablets if they are broken, cracked, or damaged.
Take your doses of Verzenio at about the same time every day.
If you vomit or miss a dose of Verzenio, take your next dose at your regular time. Do not take 2 doses at the same time to make up for the missed dose.

What to avoid during treatment

Avoid taking ketoconazole during treatment with Verzenio. Tell your healthcare provider if you take a medicine that contains ketoconazole
Avoid grapefruit and products that contain grapefruit during treatment with Verzenio. Grapefruit may increase the amount of Verzenio in your blood

Learn more

Verzenio is a prescription medicine. For more information, call 1-800-545-5979.

This summary provides basic information about Verzenio but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Verzenio and how to take it. Your healthcare provider is the best person to help you decide if Verzenio is right for you.

AL CON BS 03MAR2023

Verzenio^® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

INDICATIONS

Verzenio^® (ver-ZEN-ee-oh) is used to treat certain types of breast cancer known as HR+/HER2– (hormone receptor positive/human epidermal growth factor receptor 2 negative) breast cancer.

It is a medicine you can take if:

You have node-positive early breast cancer that has a high risk of coming back as determined by your healthcare provider. Verzenio is given along with hormonal therapy to women and men.
Or, the cancer has spread to other parts of the body (metastasized). If you are female or male, then Verzenio is given with an aromatase inhibitor as initial endocrine-based therapy. If you are a female or male, and the cancer has gotten worse after hormonal therapy, then Verzenio is given with fulvestrant. If you are female or male and the cancer has gotten worse after both hormonal therapy and chemotherapy, then Verzenio is given by itself.

It is not known if Verzenio is safe and effective in children.